Vesicle docking involved in exocytosis

Across TCGA patient cohorts, RNA activity of the Vesicle docking involved in exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAIP, RBL1, and HROB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle docking involved in exocytosis activity versus TRAIP in UCEC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAIP →	-0.911	-0.285	<.001	<.001	3	6
COAD	RBL1 →	-0.459	-0.150	<.001	<.001	3	6
UCEC	HROB →	-0.619	-0.253	<.001	<.001	3	6
UCEC	PPIL1 →	-0.696	-0.265	.002	<.001	3	6
BRCA	BIRC5 →	-1.032	-0.184	<.001	<.001	3	6
BRCA	PRR11 →	-0.682	-0.229	.005	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006904 vs TRAIP — UCEC

Explore this scatter interactively →