Vesicle targeting

Across TCGA cell cohorts, RNA activity of the Vesicle targeting pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAPOLG, FOXD2, and STK17A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PAPOLG grouped by Vesicle targeting-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PAPOLG →	+0.145	+0.611	<.001	.007	2	4
STOMACH	FOXD2 →	+0.164	+1.019	.004	.002	3	3
OESOPHAGUS	STK17A →	-0.167	-0.988	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	NLRP3 →	-0.176	-1.140	<.001	.002	3	3
LARGE_INTESTINE	TRAF3IP3 →	-0.266	-1.089	<.001	.005	3	3
OESOPHAGUS	CTTNBP2 →	-0.078	-1.115	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PAPOLG by Vesicle targeting activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →