Vesicle coating

Across TCGA cell cohorts, RNA activity of the Vesicle coating pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NBPF20, JADE2, and STARD9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NBPF20 grouped by Vesicle coating-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NBPF20 →	-0.791	-0.499	.007	.006	3	4
LUNG_SCLC	JADE2 →	-1.723	-0.332	.002	.004	3	4
LIVER	STARD9 →	-1.525	-0.521	.001	<.001	3	4
LIVER	SOWAHC →	+0.931	+0.566	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	BOLA2B →	+1.275	+0.433	.001	.001	3	4
SKIN	FMR1 →	-0.457	-0.402	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NBPF20 by Vesicle coating activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →