Golgi to vacuole transport

Across TCGA cell cohorts, RNA activity of the Golgi to vacuole transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL24, ZNF92, and VPREB3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi to vacuole transport activity versus KLHL24 in BLOOD_Leukemia (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KLHL24 →	-0.762	-0.583	.002	.002	3	4
BLOOD_Leukemia	ZNF92 →	-0.747	-0.714	<.001	<.001	3	4
BLOOD_Lymphoma	VPREB3 →	-5.077	-0.900	<.001	<.001	3	4
BLOOD_Lymphoma	SLC43A1 →	-3.282	-0.948	<.001	.001	3	4
BLOOD_Lymphoma	PLCB3 →	+1.460	+1.142	<.001	<.001	3	3
SOFT_TISSUE	C1orf52 →	-1.274	-0.401	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006896 vs KLHL24 — BLOOD_Leukemia

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