Golgi to endosome transport

Across TCGA cell cohorts, RNA activity of the Golgi to endosome transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCSK5, SLC23A3, and PROKR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCSK5 grouped by Golgi to endosome transport-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PCSK5 →	+0.240	+0.085	.002	<.001	3	5
BLOOD_Myeloma	SLC23A3 →	+0.171	+0.074	.001	.003	3	4
SOFT_TISSUE	PROKR2 →	+0.198	+0.054	.001	.004	3	4
STOMACH	RARG →	-0.238	-0.147	.004	.004	3	4
BREAST	HNRNPA1P10 →	-0.232	-0.102	.001	.001	3	4
LUNG_SCLC	TSNARE1 →	+0.301	+0.086	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCSK5 by Golgi to endosome transport activity — LUNG_SCLC

Explore this box plot interactively →