Golgi to plasma membrane transport

Across TCGA cell cohorts, RNA activity of the Golgi to plasma membrane transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDHD1, ACTR3C, and YBX1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi to plasma membrane transport activity versus DDHD1 in PANCREAS (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DDHD1 →	-0.771	-0.282	<.001	<.001	3	6
PANCREAS	ACTR3C →	+1.445	+0.340	.009	.006	3	6
BREAST	YBX1 →	-1.106	-0.198	.002	.004	3	6
LUNG_SCLC	KRT18 →	+4.004	+0.316	<.001	<.001	3	6
OVARY	PPL →	+2.806	+0.256	<.001	.001	3	6
OVARY	TINAGL1 →	+3.735	+0.275	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006893 vs DDHD1 — PANCREAS

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