Post-Golgi vesicle-mediated transport

Across TCGA patient cohorts, RNA activity of the Post-Golgi vesicle-mediated transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are YME1L1, RPL5, and SERBP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Post-Golgi vesicle-mediated transport activity versus YME1L1 in BRCA (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	YME1L1 →	-0.301	-0.039	<.001	<.001	3	8
BRCA	RPL5 →	-0.232	-0.044	<.001	<.001	3	8
HNSC	SERBP1 →	-0.276	-0.063	<.001	.001	3	7
OV	CLPX →	-0.284	-0.059	<.001	.002	3	7
BRCA	MMP2 →	+0.694	+0.033	<.001	<.001	3	7
BRCA	PALM →	+0.765	+0.049	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006892 vs YME1L1 — BRCA

Explore this scatter interactively →