Post-Golgi vesicle-mediated transport

Across TCGA patient cohorts, RNA activity of the Post-Golgi vesicle-mediated transport pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTRF1, SCML2, and ANKRD16, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Post-Golgi vesicle-mediated transport activity versus MTRF1 in HNSC (Pearson r = -0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MTRF1 →	-0.683	-0.244	.004	.003	3	3
COAD	SCML2 →	-0.514	-0.162	.007	.001	3	3
COAD	ANKRD16 →	-0.337	-0.121	<.001	.001	3	3
COAD	RRS1 →	-0.532	-0.183	<.001	<.001	3	3
COAD	RPL36AP13 →	-0.430	-0.155	.007	.002	3	3
COAD	JMJD4 →	-0.244	-0.111	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006892 vs MTRF1 — HNSC

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