Post-Golgi vesicle-mediated transport

Across TCGA cell cohorts, RNA activity of the Post-Golgi vesicle-mediated transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYSF, EEF1B2, and SLC2A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Post-Golgi vesicle-mediated transport activity versus DYSF in LIVER (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DYSF →	+2.964	+0.203	.001	.003	3	6
PANCREAS	EEF1B2 →	-0.640	-0.222	.007	.002	3	5
LIVER	SLC2A1 →	+2.444	+0.258	<.001	<.001	3	5
BONE	PHF11 →	+2.352	+0.134	.003	.007	2	6
STOMACH	MBOAT7 →	+1.405	+0.183	.005	.007	2	6
STOMACH	MYG1 →	-0.729	-0.210	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006892 vs DYSF — LIVER

Explore this scatter interactively →