Intra-Golgi vesicle-mediated transport

Across TCGA patient cohorts, RNA activity of the Intra-Golgi vesicle-mediated transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1A_S667, MAP1A, and MAP1A_S2106, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intra-Golgi vesicle-mediated transport activity versus MAP1A_S667 in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAP1A_S667 →	+0.552	+0.040	.001	<.001	3	7
LSCC	MAP1A →	+0.356	+0.028	<.001	<.001	3	7
BRCA	MAP1A_S2106 →	+0.560	+0.034	.001	.001	3	7
OV	FRZB →	+0.943	+0.046	<.001	.001	3	6
LUAD	MAP1A_S2022 →	+0.659	+0.030	<.001	.004	3	6
GBM	C1orf198 →	+0.587	+0.042	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006891 vs MAP1A_S667 — BRCA

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