Intra-Golgi vesicle-mediated transport

Across TCGA pan-cancer cohorts, RNA activity of the Intra-Golgi vesicle-mediated transport pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 34 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Intra-Golgi vesicle-mediated transport pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and HNSC, show the opposite pattern, with higher activity associated with better survival.

UVM, UCS, and SCLC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.303	0.712	<.001	88	view →
UCS	DFS	Quartile	II,III,IV	0.678	0.127	<.001	46	view →
SCLC	OS	Median	All	0.501	1.000	<.001	23	view →
HNSC	OS	Tertile	IV	0.603	0.432	.013	18	view →
ACC	OS	Median	IV	1.000	0.347	.009	18	view →
LUAD	OS	Median	II,III,IV	0.774	0.657	.008	16	view →
KIRP	OS	Median	All	0.497	0.776	.009	14	view →
THCA	DFS	Median	IV	0.591	0.873	.008	13	view →
MESO	DFS	Median	All	0.312	0.544	.040	12	view →
PAAD	OS	Tertile	II,III,IV	0.588	0.276	.019	12	view →
PRAD	DFS	Tertile	All	0.974	0.904	.008	8	view →
COAD	DFS	Median	All	0.677	0.421	.029	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0006891–UVM (DFS)

Open the UVM breakdown →