Intra-Golgi vesicle-mediated transport

Across TCGA patient cohorts, RNA activity of the Intra-Golgi vesicle-mediated transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC24D, PARK7, and TXNDC11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intra-Golgi vesicle-mediated transport activity versus SEC24D in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEC24D →	+0.593	+0.182	.002	.001	3	5
CCRCC	PARK7 →	-0.253	-0.177	<.001	<.001	3	4
BRCA	TXNDC11 →	+0.351	+0.205	<.001	.001	3	4
BRCA	IMPDH1P8 →	-0.833	-0.230	<.001	<.001	3	4
LSCC	DGKG →	+0.546	+0.155	.007	<.001	3	4
OV	CPM →	+0.802	+0.138	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006891 vs SEC24D — BRCA

Explore this scatter interactively →