Intra-Golgi vesicle-mediated transport

Across TCGA cell cohorts, RNA activity of the Intra-Golgi vesicle-mediated transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPCAT4, MYDGF, and TXNIP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LPCAT4 grouped by Intra-Golgi vesicle-mediated transport-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LPCAT4 →	+1.832	+0.400	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	MYDGF →	+1.088	+0.241	.004	.001	3	4
BREAST	TXNIP →	+2.452	+0.188	<.001	<.001	3	4
LARGE_INTESTINE	HSPG2 →	+1.597	+0.237	.002	.006	3	4
LUNG_NSCLC_LUSC	CENPL →	-1.110	-0.182	.003	.002	3	4
LUNG_NSCLC_LUSC	BAZ2A →	-0.734	-0.174	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LPCAT4 by Intra-Golgi vesicle-mediated transport activity — BLOOD_Lymphoma

Explore this box plot interactively →