Intra-Golgi vesicle-mediated transport

Across TCGA cell cohorts, RNA activity of the Intra-Golgi vesicle-mediated transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TXLNA, EBPL, and LIN7B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intra-Golgi vesicle-mediated transport activity versus TXLNA in LARGE_INTESTINE (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TXLNA →	+0.469	+0.559	.005	.009	3	5
BLOOD_Myeloma	EBPL →	-1.019	-0.158	<.001	.001	3	4
LUNG_NSCLC_LUSC	LIN7B →	+1.445	+0.389	<.001	<.001	3	4
LUNG_NSCLC_LUSC	NCDN →	+0.810	+0.388	.008	.001	2	5
LARGE_INTESTINE	CABIN1 →	+0.738	+0.576	.001	.007	3	4
BLOOD_Lymphoma	MEF2C →	+2.096	+0.225	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006891 vs TXLNA — LARGE_INTESTINE

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