"Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"

Across TCGA cell cohorts, RNA activity of the "Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCTD21, PDIA3, and NOMO2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCTD21 grouped by "Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KCTD21 →	+1.067	+0.322	.004	.007	2	5
PANCREAS	PDIA3 →	+0.744	+0.203	.005	.004	3	4
BLOOD_Leukemia	NOMO2 →	+0.938	+0.260	<.001	<.001	3	4
OVARY	C1QBP →	-0.850	-0.214	.009	.001	2	5
BLOOD_Leukemia	DHX9 →	-0.731	-0.301	.001	<.001	3	4
OVARY	TXLNG →	-0.623	-0.118	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCTD21 by "Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" activity — BLOOD_Myeloma

Explore this box plot interactively →