"Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"

Across TCGA cell cohorts, RNA activity of the "Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNA12, SEC24A, and CREB3L1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" activity versus GNA12 in LUNG_NSCLC_LUAD (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GNA12 →	+0.677	+0.146	.003	.002	3	6
URINARY_TRACT	SEC24A →	+0.717	+0.354	<.001	.003	3	6
BREAST	CREB3L1 →	+3.427	+0.222	<.001	.003	2	7
LIVER	CLIC1 →	+1.304	+0.233	.001	.003	3	6
URINARY_TRACT	TMF1 →	+0.968	+0.443	.002	.004	3	6
CNS	SSR1 →	+0.703	+0.184	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006890 vs GNA12 — LUNG_NSCLC_LUAD

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