"Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"

Across TCGA cell cohorts, RNA activity of the "Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARF4, SEC23A, and COPB1, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" activity versus ARF4 in URINARY_TRACT (Pearson r = 0.71).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ARF4 →	+1.684	+0.448	.001	.001	2	17
BREAST	SEC23A →	+1.500	+0.235	<.001	<.001	3	14
URINARY_TRACT	COPB1 →	+1.561	+0.346	.005	.003	2	15
URINARY_TRACT	COPA →	+1.515	+0.390	.001	.002	2	14
BLOOD_Myeloma	TMED7 →	+1.601	+0.238	.003	.009	3	13
URINARY_TRACT	COPZ1 →	+2.265	+0.429	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006890 vs ARF4 — URINARY_TRACT

Explore this scatter interactively →