Endoplasmic reticulum to Golgi vesicle-mediated transport

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum to Golgi vesicle-mediated transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UCHL1, MAP1A, and HSPA12A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum to Golgi vesicle-mediated transport activity versus UCHL1 in LUAD (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	UCHL1 →	+0.742	+0.020	<.001	.003	3	6
BRCA	MAP1A →	+0.392	+0.023	.002	.002	3	6
LSCC	HSPA12A →	+0.294	+0.024	<.001	.002	3	6
CCRCC	RTN1 →	+0.487	+0.029	<.001	<.001	2	6
LSCC	SEPTIN4 →	+0.253	+0.022	<.001	.006	3	5
OV	SRRM1_S431 →	-0.746	-0.029	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006888 vs UCHL1 — LUAD

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