Endoplasmic reticulum to Golgi vesicle-mediated transport

Across TCGA pan-cancer cohorts, RNA activity of the Endoplasmic reticulum to Golgi vesicle-mediated transport pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 137 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Endoplasmic reticulum to Golgi vesicle-mediated transport pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

KIRC, LGG, and CESC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.492	0.695	<.001	142	view →
LGG	DFS	Median	All	0.665	0.790	<.001	51	view →
CESC	DFS	Tertile	III,IV	0.504	0.823	.001	34	view →
UVM	DFS	Quartile	II,III,IV	0.242	0.774	<.001	33	view →
KIRP	DFS	Median	All	0.341	0.728	<.001	32	view →
HNSC	DFS	Tertile	III,IV	0.716	0.548	.006	30	view →
MESO	DFS	Tertile	All	0.348	0.669	.019	27	view →
SCLC	OS	Median	All	0.551	1.000	.002	23	view →
LIHC	OS	Median	All	0.632	0.749	.018	18	view →
SKCM	OS	Median	III,IV	0.483	0.311	.003	17	view →
ACC	DFS	Tertile	All	0.495	0.819	.012	14	view →
ESCA	OS	Median	III,IV	0.629	0.335	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0006888–KIRC (OS)

Open the KIRC breakdown →