Endoplasmic reticulum to Golgi vesicle-mediated transport

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum to Golgi vesicle-mediated transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFNB3, KRT17, and RARG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum to Golgi vesicle-mediated transport activity versus EFNB3 in CCRCC (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	EFNB3 →	-0.472	-0.149	<.001	<.001	3	5
CCRCC	KRT17 →	-0.438	-0.138	.004	<.001	3	5
CCRCC	RARG →	-0.320	-0.146	<.001	<.001	3	5
UCEC	DHX35 →	-0.816	-0.367	<.001	<.001	3	4
UCEC	CREB3L1 →	+1.631	+0.254	.004	.003	3	4
HNSC	FANCE →	-0.916	-0.149	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006888 vs EFNB3 — CCRCC

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