Endoplasmic reticulum to Golgi vesicle-mediated transport

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum to Golgi vesicle-mediated transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FUT4, TCN2, and PNN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FUT4 grouped by Endoplasmic reticulum to Golgi vesicle-mediated transport-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FUT4 →	+1.430	+0.272	<.001	.003	3	5
OVARY	TCN2 →	+1.664	+0.152	.002	.003	3	5
BREAST	PNN →	-0.398	-0.121	.007	.001	3	4
BREAST	SRSF7 →	-0.511	-0.177	<.001	<.001	3	4
BREAST	TIGD3 →	-0.767	-0.130	.001	.009	3	4
BREAST	NOP58 →	-0.462	-0.140	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FUT4 by Endoplasmic reticulum to Golgi vesicle-mediated transport activity — PANCREAS

Explore this box plot interactively →