Endoplasmic reticulum to Golgi vesicle-mediated transport

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum to Golgi vesicle-mediated transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC24D, COPG1, and FAM174A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum to Golgi vesicle-mediated transport activity versus SEC24D in LIVER (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SEC24D →	+1.242	+0.223	.004	.009	3	7
LIVER	COPG1 →	+0.892	+0.223	.001	.009	3	7
LUNG_SCLC	FAM174A →	+1.202	+0.212	<.001	<.001	3	6
BLOOD_Myeloma	ERLEC1 →	+1.218	+0.295	.001	.007	3	6
OVARY	SLC35A2 →	+0.722	+0.169	.005	<.001	3	6
OVARY	CREB3 →	+0.931	+0.202	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006888 vs SEC24D — LIVER

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