Endoplasmic reticulum to Golgi vesicle-mediated transport

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum to Golgi vesicle-mediated transport pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCFD1, CLTC, and COPB2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum to Golgi vesicle-mediated transport activity versus SCFD1 in STOMACH (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SCFD1 →	+0.989	+0.225	.002	<.001	3	14
BONE	CLTC →	+0.737	+0.245	.005	<.001	3	13
LIVER	COPB2 →	+0.879	+0.226	.008	.009	3	13
BONE	TMED9 →	+0.908	+0.209	<.001	<.001	3	13
BLOOD_Lymphoma	TMED2 →	+1.066	+0.162	<.001	<.001	3	12
BONE	TMED10 →	+0.768	+0.208	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006888 vs SCFD1 — STOMACH

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