Cell volume homeostasis

Across TCGA cell cohorts, RNA activity of the Cell volume homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLE5, HOXA1, and NABP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell volume homeostasis activity versus TLE5 in BONE (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TLE5 →	+1.438	+1.186	.006	.006	3	5
URINARY_TRACT	HOXA1 →	-1.232	-1.812	<.001	<.001	3	5
LARGE_INTESTINE	NABP1 →	-1.828	-0.828	<.001	.003	3	5
LIVER	RBKS →	-1.057	-1.384	.007	.001	3	5
SKIN	ZKSCAN2 →	+0.732	+1.554	.001	<.001	3	5
CNS	UQCRC2 →	+0.542	+0.964	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006884 vs TLE5 — BONE

Explore this scatter interactively →