Intracellular zinc ion homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular zinc ion homeostasis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF2A1, HSD3B2, and GLRB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTF2A1 grouped by Intracellular zinc ion homeostasis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GTF2A1 →	+0.243	+0.424	.001	<.001	3	4
CNS	HSD3B2 →	+0.245	+0.397	.007	.002	3	3
PANCREAS	GLRB →	-0.177	-1.086	.008	.004	3	3
PANCREAS	GPS2 →	+0.275	+1.270	.001	.001	2	4
LARGE_INTESTINE	CPAMD8 →	-0.156	-0.325	.004	<.001	3	3
LARGE_INTESTINE	TRMT10B →	+0.261	+0.400	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTF2A1 by Intracellular zinc ion homeostasis activity — LUNG_SCLC

Explore this box plot interactively →