Amino acid transport

Across TCGA cell cohorts, RNA activity of the Amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH6A1, PBX1, and TYRP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALDH6A1 grouped by Amino acid transport-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ALDH6A1 →	+0.929	+0.938	.007	.001	3	5
SKIN	PBX1 →	+0.839	+1.479	<.001	<.001	3	4
BONE	TYRP1 →	-0.357	-1.773	<.001	<.001	3	4
SOFT_TISSUE	CCDC28A →	+1.027	+1.084	.006	.003	3	4
LIVER	CDKN1B →	+0.801	+1.116	.001	.004	3	4
BONE	NDRG4 →	-1.481	-1.495	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALDH6A1 by Amino acid transport activity — LARGE_INTESTINE

Explore this box plot interactively →