Mitochondrial calcium ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Mitochondrial calcium ion transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRRM1_S628, MCUB, and TACC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial calcium ion transmembrane transport activity versus SRRM1_S628 in OV (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SRRM1_S628 →	-1.027	-0.055	.001	<.001	3	4
OV	MCUB →	+0.471	+0.048	<.001	<.001	3	4
GBM	TACC1 →	+0.173	+0.036	.007	.005	2	5
GBM	FKBP9 →	-0.484	-0.040	<.001	.005	2	5
PDAC	TLN1_S1225 →	-0.190	-0.028	.003	.008	3	4
PDAC	LMNA_S392 →	-0.354	-0.041	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006851 vs SRRM1_S628 — OV

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