Mitochondrial calcium ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Mitochondrial calcium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCBD1, SLC25A23, and MCU, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial calcium ion transmembrane transport activity versus PCBD1 in BLOOD_Leukemia (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PCBD1 →	+1.443	+0.067	<.001	<.001	3	11
BLOOD_Leukemia	SLC25A23 →	+1.213	+0.101	<.001	<.001	3	9
STOMACH	MCU →	+0.832	+0.082	.003	.001	3	9
OVARY	MUC1 →	+2.957	+0.113	<.001	<.001	3	8
BONE	TEC →	+0.909	+0.063	.001	.006	3	8
OVARY	TSPAN15 →	+2.396	+0.115	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006851 vs PCBD1 — BLOOD_Leukemia

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