Mitochondrial calcium ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Mitochondrial calcium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LETM1, MRPS18B, and USP14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial calcium ion transmembrane transport activity versus LETM1 in BREAST (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LETM1 →	+0.811	+0.220	<.001	.001	2	6
BLOOD_Myeloma	MRPS18B →	+0.846	+0.171	.004	.003	3	4
LIVER	USP14 →	+0.729	+0.208	.002	.005	3	4
KIDNEY	TRMT10C →	+0.758	+0.286	.005	.004	2	5
URINARY_TRACT	PLXNB3 →	-1.942	-0.250	.004	.005	3	4
SOFT_TISSUE	NEK7 →	-2.125	-0.287	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006851 vs LETM1 — BREAST

Explore this scatter interactively →