Serotonin transport

Across TCGA patient cohorts, RNA activity of the Serotonin transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WAS, GTF3C4, and RFC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serotonin transport activity versus WAS in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WAS →	+0.411	+0.085	<.001	<.001	3	8
LSCC	GTF3C4 →	-0.324	-0.047	<.001	<.001	3	7
LSCC	RFC1 →	-0.297	-0.057	.001	.001	3	7
LSCC	TOMM70 →	-0.290	-0.038	<.001	.003	3	7
LSCC	DOCK11 →	+0.285	+0.043	<.001	<.001	3	7
GBM	PTPN6 →	+0.656	+0.112	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006837 vs WAS — GBM

Explore this scatter interactively →