Serotonin transport

Across TCGA patient cohorts, RNA activity of the Serotonin transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR2D, FKBP9, and AMMECR1L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serotonin transport activity versus POLR2D in PDAC (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	POLR2D →	-0.215	-0.861	.003	.002	3	5
LSCC	FKBP9 →	-0.376	-0.422	.004	.004	3	4
PDAC	AMMECR1L →	-0.231	-1.032	<.001	<.001	3	4
PDAC	UBTD2 →	-0.328	-0.894	.001	.002	3	4
PDAC	ELP1 →	-0.245	-0.873	.002	.002	3	4
OV	ARL1 →	-0.294	-0.253	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006837 vs POLR2D — PDAC

Explore this scatter interactively →