Neurotransmitter transport

Across TCGA patient cohorts, RNA activity of the Neurotransmitter transport pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are INTS13, SYT7, and PPFIA3_S683, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter transport activity versus INTS13 in HNSC (Pearson r = -0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	INTS13 →	-0.189	-0.026	.001	.003	3	6
GBM	SYT7 →	+0.983	+0.065	<.001	<.001	3	5
GBM	PPFIA3_S683 →	+0.678	+0.056	<.001	<.001	3	5
GBM	RAB24 →	+0.251	+0.050	<.001	<.001	3	5
BRCA	STARD10 →	+0.726	+0.022	<.001	<.001	3	5
LSCC	VPS52 →	+0.148	+0.023	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006836 vs INTS13 — HNSC

Explore this scatter interactively →