Dicarboxylic acid transport

Across TCGA cell cohorts, RNA activity of the Dicarboxylic acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPC2, UBE2H, and ROBO3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dicarboxylic acid transport activity versus NPC2 in LIVER (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NPC2 →	+2.370	+0.256	<.001	.006	3	5
LIVER	UBE2H →	+1.321	+0.190	<.001	.005	3	5
STOMACH	ROBO3 →	-2.643	-0.342	<.001	.001	3	4
OVARY	SLC1A3 →	+2.766	+0.309	.003	.003	3	4
LARGE_INTESTINE	NEURL3 →	+0.862	+0.175	<.001	.003	3	4
LARGE_INTESTINE	RHOBTB3 →	+2.033	+0.202	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006835 vs NPC2 — LIVER

Explore this scatter interactively →