Zinc ion transport

Across TCGA cell cohorts, RNA activity of the Zinc ion transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAAF3, HLA-B, and SPDYA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAAF3 grouped by Zinc ion transport-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DNAAF3 →	+1.179	+0.832	.007	.004	3	5
URINARY_TRACT	HLA-B →	-4.094	-1.614	<.001	<.001	3	4
KIDNEY	SPDYA →	+0.563	+1.505	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	EDF1 →	+0.954	+1.441	<.001	<.001	3	4
LUNG_SCLC	IFITM3 →	-5.061	-1.705	.004	<.001	3	3
LUNG_SCLC	PSMB8 →	-2.367	-1.056	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAAF3 by Zinc ion transport activity — BREAST

Explore this box plot interactively →