Copper ion transport

Across TCGA patient cohorts, RNA activity of the Copper ion transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR4666A, MIR4740, and PNPLA1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Copper ion transport activity versus MIR4666A in OV (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MIR4666A →	+0.883	+0.106	.007	.007	3	3
BRCA	MIR4740 →	-0.984	-0.650	<.001	<.001	3	3
HNSC	PNPLA1 →	+0.735	+0.100	<.001	<.001	3	2
HNSC	SYNM →	-0.738	-0.123	.007	.002	2	3
HNSC	RNU4-62P →	-1.109	-0.123	.002	.003	3	2
HNSC	BOLA3-AS1 →	-0.425	-0.106	.006	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006825 vs MIR4666A — OV

Explore this scatter interactively →