Cobalt ion transport

Across TCGA patient cohorts, RNA activity of the Cobalt ion transport pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNA5SP217, MLPH, and HSPE1P14, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cobalt ion transport activity versus RNA5SP217 in COAD (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNA5SP217 →	-1.157	-0.679	<.001	.007	3	3
HNSC	MLPH →	+0.609	+0.653	.008	<.001	3	3
HNSC	HSPE1P14 →	-0.370	-0.453	.003	.008	3	3
UCEC	MUC5B →	+2.078	+0.429	.003	.005	3	3
LUAD	ASCL5 →	-0.524	-0.730	.003	<.001	3	3
BRCA	CGNL1 →	+0.568	+0.534	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006824 vs RNA5SP217 — COAD

Explore this scatter interactively →