Sodium ion transport

Across TCGA patient cohorts, RNA activity of the Sodium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NKG7, TMEM254, and CD72, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sodium ion transport activity versus NKG7 in BRCA (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NKG7 →	-1.044	-0.386	.004	.005	3	3
BRCA	TMEM254 →	+0.543	+0.547	<.001	<.001	3	3
BRCA	CD72 →	-0.612	-0.458	.004	.006	3	3
COAD	SLC22A18AS →	+0.335	+0.477	.007	.003	3	3
HNSC	CD99L2 →	-0.787	-1.964	.004	.005	3	3
HNSC	CRABP1 →	-1.458	-2.045	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006814 vs NKG7 — BRCA

Explore this scatter interactively →