Xenobiotic metabolic process

Across TCGA cell cohorts, RNA activity of the Xenobiotic metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NQO1, ACBD5, and GSR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenobiotic metabolic process activity versus NQO1 in LUNG_SCLC (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NQO1 →	+2.115	+0.234	<.001	<.001	3	7
URINARY_TRACT	ACBD5 →	+1.012	+0.578	.004	.003	3	6
SKIN	GSR →	+0.948	+0.345	<.001	<.001	3	5
SKIN	VPS26C →	+0.915	+0.337	<.001	<.001	3	5
SKIN	GSTM4 →	+1.487	+0.261	<.001	.004	3	5
SKIN	TANGO2 →	+1.482	+0.276	.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006805 vs NQO1 — LUNG_SCLC

Explore this scatter interactively →