Vitamin A metabolic process

Across TCGA patient cohorts, RNA activity of the Vitamin A metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WSCD1, ALDH1A2, and LHFPL6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin A metabolic process activity versus WSCD1 in BRCA (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WSCD1 →	+0.284	+0.118	.007	.003	3	6
OV	ALDH1A2 →	+1.394	+0.105	<.001	<.001	3	5
OV	LHFPL6 →	+0.965	+0.100	<.001	<.001	3	5
BRCA	ACKR1 →	+1.319	+0.128	.002	.002	3	5
OV	FHL5 →	+0.669	+0.098	<.001	<.001	3	4
OV	ST3GAL5 →	+0.536	+0.112	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006776 vs WSCD1 — BRCA

Explore this scatter interactively →