Vitamin metabolic process

Across TCGA cell cohorts, RNA activity of the Vitamin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TXN2, LONP1, and PSAT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin metabolic process activity versus TXN2 in STOMACH (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TXN2 →	+1.073	+1.781	.004	<.001	3	6
LUNG_SCLC	LONP1 →	+0.498	+0.517	<.001	.004	3	6
BLOOD_Leukemia	PSAT1 →	+2.306	+0.956	<.001	<.001	3	6
LARGE_INTESTINE	EDN1 →	-1.931	-1.285	.001	<.001	3	6
SKIN	TIMM44 →	+0.818	+0.943	.006	.007	2	6
PANCREAS	CNNM4 →	+0.680	+1.036	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006766 vs TXN2 — STOMACH

Explore this scatter interactively →