ATP biosynthetic process

Across TCGA cell cohorts, RNA activity of the ATP biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5PD, ATP5PO, and COX7C, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP5PD grouped by ATP biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ATP5PD →	-0.471	-0.283	<.001	<.001	3	12
LUNG_SCLC	ATP5PO →	-0.435	-0.449	<.001	<.001	3	10
BREAST	COX7C →	-0.231	-0.376	<.001	<.001	3	8
URINARY_TRACT	MRPL38 →	-0.577	-0.337	.008	.002	1	9
LARGE_INTESTINE	COX4I1 →	-0.347	-0.252	<.001	<.001	3	7
BREAST	UQCRC2 →	-0.490	-0.329	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP5PD by ATP biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →