ATP biosynthetic process

Across TCGA cell cohorts, RNA activity of the ATP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INPP1, PDK2, and SH3PXD2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INPP1 grouped by ATP biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	INPP1 →	-1.228	-0.322	.006	.004	3	4
LUNG_SCLC	PDK2 →	-1.543	-0.282	.002	.008	3	4
LUNG_NSCLC_LUAD	SH3PXD2A →	-1.102	-0.267	.006	.004	3	4
BREAST	ATP2C2 →	+1.756	+0.316	<.001	<.001	3	4
BREAST	CDC14B →	-1.204	-0.233	<.001	.007	3	4
URINARY_TRACT	LGALS3BP →	-1.873	-0.668	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INPP1 by ATP biosynthetic process activity — BREAST

Explore this box plot interactively →