Glutathione catabolic process

Across TCGA cell cohorts, RNA activity of the Glutathione catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF14, HERC6, and KLF4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNFRSF14 grouped by Glutathione catabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TNFRSF14 →	-2.559	-1.455	<.001	<.001	3	3
STOMACH	HERC6 →	+1.599	+0.931	.003	.006	3	3
LUNG_NSCLC_LUAD	KLF4 →	+1.669	+1.112	<.001	<.001	3	3
OVARY	GCHFR →	+1.931	+0.933	<.001	<.001	3	3
OVARY	HOMER3 →	-1.420	-1.339	<.001	<.001	3	3
BREAST	DCTPP1 →	+0.850	+0.749	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNFRSF14 by Glutathione catabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →