Glutathione catabolic process

Across TCGA cell cohorts, RNA activity of the Glutathione catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRSF2, PIGG, and SLC36A1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRSF2 grouped by Glutathione catabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SRSF2 →	+0.418	+0.747	<.001	.004	3	3
BLOOD_Lymphoma	PIGG →	-0.362	-0.176	.007	.009	3	3
BLOOD_Lymphoma	SLC36A1 →	+0.325	+0.152	<.001	.005	3	3
BLOOD_Leukemia	CAPN15 →	-0.301	-0.207	.001	.001	3	3
BLOOD_Leukemia	SRSF3 →	+0.213	+0.180	.006	<.001	3	3
BLOOD_Leukemia	ECE1 →	+0.275	+0.146	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRSF2 by Glutathione catabolic process activity — OVARY

Explore this box plot interactively →