NADP metabolic process

Across TCGA patient cohorts, RNA activity of the NADP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ME1, DOCK4_S1620, and NELFE_S251, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NADP metabolic process activity versus ME1 in UCEC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ME1 →	+0.582	+0.059	.006	.001	2	6
UCEC	DOCK4_S1620 →	-0.632	-0.121	.002	<.001	3	5
LSCC	NELFE_S251 →	+0.345	+0.033	.001	.001	3	5
PDAC	ADD1_S481 →	+0.395	+0.027	<.001	<.001	3	5
PDAC	ALDH1A1_S413 →	+0.618	+0.032	<.001	<.001	3	5
GBM	MAP1A_S2022 →	+0.557	+0.039	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006739 vs ME1 — UCEC

Explore this scatter interactively →