One-carbon metabolic process

Across TCGA patient cohorts, RNA activity of the One-carbon metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CA9, VPS18, and TRIM3_S7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, One-carbon metabolic process activity versus CA9 in LSCC (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CA9 →	+0.588	+0.022	.002	.005	3	6
PDAC	VPS18 →	-0.140	-0.032	.001	<.001	3	5
GBM	TRIM3_S7 →	-0.256	-0.050	.001	.003	3	4
LUAD	CA13 →	+0.547	+0.044	.002	<.001	3	4
HNSC	HIC1_S237 →	-0.584	-0.059	<.001	<.001	3	4
HNSC	HIC1_S313 →	-0.625	-0.051	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006730 vs CA9 — LSCC

Explore this scatter interactively →