Terpenoid metabolic process

Across TCGA patient cohorts, RNA activity of the Terpenoid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DHRS3, AKR1C3, and LMNB1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Terpenoid metabolic process activity versus DHRS3 in UCEC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DHRS3 →	+0.580	+0.044	.001	<.001	3	8
UCEC	AKR1C3 →	+1.656	+0.067	<.001	<.001	3	8
COAD	LMNB1 →	-0.245	-0.026	<.001	<.001	3	8
UCEC	DAXX →	-0.286	-0.046	<.001	.003	2	8
LSCC	AKR1C1 →	+1.923	+0.063	<.001	<.001	3	7
LSCC	NLRX1 →	+0.281	+0.032	.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006721 vs DHRS3 — UCEC

Explore this scatter interactively →