Androgen catabolic process

Across TCGA patient cohorts, RNA activity of the Androgen catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DAB2_S723, WRNIP1_S65, and MYO9A_S1223, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Androgen catabolic process activity versus DAB2_S723 in BRCA (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DAB2_S723 →	+0.612	+0.045	<.001	.006	3	6
LSCC	WRNIP1_S65 →	-0.749	-0.072	.001	<.001	3	5
LUAD	MYO9A_S1223 →	+0.722	+0.113	<.001	<.001	3	5
LUAD	PBRM1_S1453 →	-0.840	-0.104	<.001	<.001	3	5
LUAD	RPL10A →	-0.212	-0.100	<.001	.001	3	5
LSCC	SASH1_S743 →	+0.890	+0.070	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006710 vs DAB2_S723 — BRCA

Explore this scatter interactively →