Glucocorticoid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Glucocorticoid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NGLY1, PLS3, and IGFBP7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucocorticoid biosynthetic process activity versus NGLY1 in HNSC (Pearson r = -0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NGLY1 →	-0.253	-0.095	<.001	<.001	3	5
HNSC	PLS3 →	+0.457	+0.064	<.001	.004	3	5
PDAC	IGFBP7 →	+0.632	+0.064	<.001	<.001	3	5
UCEC	SEPTIN4_S325 →	+0.504	+0.063	<.001	.001	3	4
HNSC	ASRGL1 →	-0.316	-0.083	.008	.008	3	4
PDAC	CEP170B_S868 →	+0.770	+0.051	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006704 vs NGLY1 — HNSC

Explore this scatter interactively →