Glucocorticoid biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Glucocorticoid biosynthetic process pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 16 member genes.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher Glucocorticoid biosynthetic process pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and LAML, show the opposite pattern, with higher activity associated with better survival.

OV, KIRC, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	All	0.266	0.361	.011	52	view →
KIRC	DFS	Tertile	II,III,IV	0.276	0.593	.004	52	view →
MESO	OS	Tertile	All	0.277	0.530	.003	49	view →
THCA	DFS	Median	II,III,IV	0.256	0.885	.002	36	view →
SARC	OS	Median	All	0.390	0.633	<.001	30	view →
KIRP	DFS	Quartile	All	0.529	0.827	.002	27	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	24	view →
SKCM	OS	Median	IV	0.867	0.225	.001	23	view →
LAML	DFS	Median	All	0.563	0.241	.002	18	view →
HNSC	DFS	Quartile	IV	0.435	0.754	.004	13	view →
UCEC	OS	Quartile	All	0.901	0.955	.006	12	view →
COAD	DFS	Median	All	0.725	0.825	.018	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0006704–OV (OS)

Open the OV breakdown →